It is very common for your symptoms to return about 24 hours after taking Allegra (fexofenadine). Fexofenadine is highly effective at controlling itching for a full day, but it only manages the symptoms rather than curing the underlying cause of your rash, which could be eczema or an allergic reaction. Once the medicine wears off, the inflammation can return. I encourage you to consult your doctor, who can help identify the root cause and recommend additional treatments, like soothing topical creams, to heal your skin.
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Why is my itchy rash returning on my neck, underarms, behind my knees, and hands 24 hours after taking Allegra?