Yes, there are excellent options to simplify your regimen. Currently, you take three pills daily. To reduce this burden, your doctor might suggest: Once-daily combinations: Switching to extended-release metformin combined with other active ingredients can reduce your dosing to just once a day. Once-weekly injections: Transitioning to a weekly GLP-1 receptor agonist can often replace both sitagliptin and glimepiride entirely, leaving you with fewer daily pills. These modern alternatives can maintain or even improve your blood sugar control. Please consult your healthcare provider to safely discuss transitioning to a more convenient regimen.