Amikacin is generally not considered safe during pregnancy. It is classified as a Category D medication, meaning there is clear evidence of risk to the unborn baby, particularly the potential to cause permanent hearing loss (ototoxicity) and kidney damage. It should only be used in life-threatening situations where safer antibiotics are not effective. I strongly advise you to consult your wife's obstetrician or prescribing doctor immediately to discuss safer alternative antibiotics, such as certain penicillins or cephalosporins, which are much safer to use during pregnancy.