Iron and vitamin D3 supplements can usually be taken with other medicines, but combining them with Ayurvedic remedies may sometimes cause unwanted interactions. Amitriptyline should also be used carefully with other treatments. It is best to take different medicines at separate times and avoid self-mixing treatments. Consult your doctor to confirm that all the medicines you are taking are safe to use together.

Severe depression that does not improve with medicines needs proper medical review and support. Speak openly with a psychiatrist so your treatment plan can be reassessed and adjusted if needed. Counselling, regular sleep, and support from family or trusted people can also help improve recovery. Seek medical help urgently if feelings of hopelessness become overwhelming or if you have thoughts of harming yourself.