Yes, it is safe to switch from Amlopress 5 to Valsartan 80 under your doctor?s guidance. Actually, Valsartan does not cause heart or kidney failure; it is highly beneficial and is actively used to treat heart failure and protect kidney function. Because it relaxes blood vessels and affects fluid balance, your doctor will likely monitor your kidney function and potassium levels with a routine blood test shortly after the switch. This is a standard safety precaution, not a sign of danger. This transition is very common, often done to improve blood pressure control or reduce side effects like ankle swelling. Please follow your doctor?s specific instructions for making the switch.