It is normal for antibiotics (amoxicillin-clavulanate) to take 24 to 48 hours to start showing improvement. However, continuous crying suggests your child is still in discomfort. Sometimes, medications like promethazine can cause a paradoxical reaction in children, leading to irritability and restlessness instead of drowsiness. Please ensure you are giving the exact prescribed doses. I recommend contacting your pediatrician today for a quick review. They can examine your child to rule out localized pain, like an ear infection, and assess if any medication adjustments are needed. If you notice rapid breathing, chest retractions, or extreme lethargy, please seek emergency medical care immediately.