For a painful, non-bleeding anal fissure lasting two weeks, treatment focuses on relaxing the muscle and relieving pain. First-line topical treatments include prescription nitroglycerin ointment or compounded diltiazem or nifedipine cream applied locally to improve blood flow and promote healing. For immediate pain relief, a topical lidocaine gel can be applied before bowel movements. Over-the-counter stool softeners or fiber supplements (like psyllium) are highly recommended to prevent straining. Additionally, taking warm sitz baths for 15 minutes twice daily helps relax the area and soothe discomfort. Please consult a doctor for a proper evaluation and prescription.