Antacids help relieve acidity and heartburn, and some work best when taken on an empty stomach because they act more quickly without food interference. Common antacids include aluminium hydroxide, magnesium hydroxide, or combination products with simethicone, but the safest choice depends on your health, other medications, and any kidney or heart conditions. Always consult your doctor before taking an antacid to ensure it is suitable for you, and follow the recommended dose and timing for effective and safe relief.