Hello. It is understandable to want to make sure your supplements and medications are safe to take together. While there is no major, highly dangerous interaction, combining THC-free CBD with hydroxyzine (Atarax) can significantly increase drowsiness, dizziness, and sleepiness. Additionally, CBD can affect how your body processes ondansetron, potentially increasing its side effects. Because of these additive effects, it is best to use caution. I gently recommend holding off on the CBD edibles until you can speak with your prescribing doctor or pharmacist. They can help you safely manage your symptoms and ensure these options are right for you.