Severe itching with hard or thickened skin may be due to chronic eczema or skin irritation. You can apply a thick moisturiser several times a day and avoid scratching. Taking an antihistamine may help reduce itching. Since your symptoms are strong, it is best to see a dermatologist for proper diagnosis and treatment.

If you have been itching all over for 40 days, taking Cetirizine alone may not be enough. Since the itching has lasted so long, it is important to see a doctor to check for underlying causes like infections, allergies, or other conditions and get appropriate treatment.

Red pimples and itching in the private area may be due to folliculitis, fungal infection, or irritation. Keep the area clean and dry, wear loose cotton clothing, and avoid scratching. You can apply a mild antifungal or antibacterial cream as recommended by a doctor. If it does not improve in a few days, see a doctor for proper treatment.

Excessive itching with kidney problems may be due to kidney-related skin changes. Keep your skin moisturised, avoid hot showers, and wear loose cotton clothes. Speak to your nephrologist, as they can recommend safe medications or creams to relieve itching without affecting your kidneys.

Since your current medicines, including Cholestyramine and Hydroxyzine, are not relieving your severe itching, you should consult your treating doctor or hepatologist. In resistant itching related to liver disease or Hepatitis A, doctors may sometimes consider medicines such as Rifampicin, Naltrexone, or Sertraline under close medical supervision. For temporary relief, take cool baths, use fragrance-free moisturizers or calamine lotion, keep your room cool, and avoid scratching. Do not start any new medicine on your own because your liver is already inflamed and some medicines may worsen liver function.