While Augmentin and sulfa drugs are chemically different?meaning an allergy to one doesn't automatically cause an allergy to the other?it is definitely possible to be sensitive to both. Fortunately, you still have several safe and effective antibiotic options. Depending on the infection you are treating, alternative classes like macrolides (such as azithromycin) or tetracyclines (such as doxycycline) are often excellent choices.
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Is it unusual to be allergic to both Augmentin and sulfa, and what other antibiotic options do I have since both cause me to get severe mouth sores?