For fast-acting results, a few pharmaceutical options are available. Oral medications known as PDE5 inhibitors are highly effective; avanafil is the fastest-acting oral option, often working within 15 to 30 minutes, while sildenafil typically takes 30 to 60 minutes to take effect. For even quicker results, alprostadil is a medication that can be administered as a small urethral suppository or via a self-injection into the side of the penis. These local treatments bypass the digestive system, typically producing a firm erection within 5 to 20 minutes. Please consult a healthcare professional to determine which option is safe and appropriate for your medical history.