Since Avil (pheniramine) has not improved your symptoms after a week, the underlying cause might not be a simple allergic reaction, or it may require a different type of treatment. I gently encourage you to consult a healthcare professional or dermatologist. They can closely examine the spots to find the exact cause?such as a localized skin infection, eczema, or another condition?and provide the right targeted therapy. For now, try to avoid scratching to prevent infection, and apply cool compresses to soothe your skin.

Since your symptoms returned after Avil (pheniramine) wore off, despite using Cetaphil and coconut oil, this might be due to nocturnal pruritus. At night, naturally occurring changes in body temperature and skin moisture can worsen itching. It could also suggest a condition like chronic hives or a localized nerve sensitivity. Because the itching is worsening, it is best to see a doctor. They can safely evaluate you and suggest longer-acting solutions to help you sleep comfortably.

Itching on your father's palms and soles without a rash, especially worsening after bathing, can be related to dry skin, diabetic nerve changes (neuropathy), or underlying liver or kidney function. Hot water strips the skin's natural oils, which can trigger this worsening. While he is taking Avil (pheniramine), it may only provide temporary relief without addressing the root cause. For comfort, have him bathe in lukewarm water and apply a thick, fragrance-free moisturizer immediately after. Please consult his doctor to check his blood sugar levels, kidney, and liver function through simple blood tests to find the exact cause and ensure his safety.

I understand how frustrating and uncomfortable this persistent itch must be, especially after 10 days. Since your symptoms are spreading despite using oral pheniramine (Avil) and topical clobetasol (Clobate), it is very important to have this re-evaluated by a healthcare provider. The skin on the neck is delicate, and because clobetasol is a highly potent steroid, continued use without improvement needs professional review. This could be an ongoing contact allergy or even a non-allergic issue, like a fungal infection, which steroids can worsen.

Your symptoms, including widespread hives, swelling, abdominal pain, and purple skin spots, suggest a systemic reaction, possibly a condition like urticarial vasculitis. Because these symptoms returned despite taking antihistamines and are accompanied by visual changes, it is very important that you seek immediate medical evaluation at an emergency department or urgent care clinic. Doctors there can safely evaluate your eyes, check your internal organs, and start appropriate treatments, which may include systemic corticosteroids. Please consult a doctor right away.

Given that your cold and sore throat have persisted, getting a COVID-19 test is a very sensible step. Even without a fever, mild infections can present this way, particularly with public transit exposure. While Avil (pheniramine) and steam inhalation can help ease congestion, they won't treat an underlying virus. I recommend taking a COVID-19 test for peace of mind. Please wear a mask during your commute, stay well-hydrated, and consult a doctor if symptoms worsen.