Beautywise Skin Brilliance is generally safe, but some people may experience mild digestive issues or, rarely, allergic reactions. Its effect on skin brightening or glow can vary depending on diet, sun exposure, and individual health. Taking it with other supplements or medications may cause interactions, and relying on it alone without good skincare and sun protection may limit results. It is best to consult a doctor or dermatologist before use, especially if you have health conditions or are pregnant.