Since over-the-counter treatments haven't worked, you likely need prescription-strength options. For stubborn acne, dermatologists often prescribe topical retinoids (like Tretinoin) to unclog pores, or combination gels containing benzoyl peroxide and Clindamycin. If topicals aren't enough, oral medications like antibiotics (Doxycycline) or hormonal therapies can help. For severe, resistant acne, oral Isotretinoin (Accutane) is the most effective cure but requires strict medical supervision due to side effects. Please consult a dermatologist who can evaluate your skin and safely prescribe the best targeted treatment for you.