While true cartilage regeneration through pills is limited because cartilage lacks a direct blood supply, several evidence-based options can support joint health, reduce pain, and slow wear and tear. The most widely researched supplements are glucosamine sulfate and chondroitin sulfate, which serve as structural building blocks for cartilage. Additionally, hydrolysed collagen and omega-3 fatty acids can help reduce joint inflammation and support tissue integrity. These options are generally safe and highly beneficial for managing mild to moderate joint discomfort. For the best results, combine these with low-impact exercise and weight management. Please consult your doctor before starting any new supplement.