Calcimax Total should not be self-administered by individuals with kidney disease without proper medical supervision. Its use may be considered in cases of mild renal impairment under close clinical monitoring; however, in moderate to severe kidney disease, it poses significant risks, including hypercalcaemia, vascular calcification, and potential deterioration of renal function. As the formulation contains calcium and vitamin D₃, which can accumulate or behave abnormally in renal disorders, its administration should be strictly guided by a nephrologist with regular evaluation of serum calcium, phosphate, and parathyroid hormone (PTH) levels to ensure safety.