Managing palmoplantar psoriasis on the feet involves targeting both the thick skin and the intense itching. For topical relief, high-potency topical corticosteroids (like clobetasol propionate) are highly effective first-line treatments, often combined with vitamin D analogues (like calcipotriene). To help these creams penetrate the thick skin on your soles, keratolytics containing salicylic acid or urea are very useful. For severe itching or persistent plaques, oral medications such as acitretin or methotrexate, or targeted biologic therapies, can provide significant relief. Please consult a dermatologist to tailor a safe, effective treatment plan. You can absolutely get this comfortable and under control.