It is common to experience fatigue and muscle soreness after drinking alcohol, often due to dehydration, electrolyte loss, and disrupted sleep. To relieve the muscle soreness, you can take a generic over-the-counter pain reliever like ibuprofen with food to protect your stomach. Avoid acetaminophen, as it can strain your liver after alcohol consumption. The most effective treatment, however, is rehydration. Drink plenty of water or electrolyte-rich fluids, and get adequate rest. If your symptoms do not improve in a day or two, or if you notice very dark urine, please consult a doctor. With rest and hydration, you should feel better soon.