Negative and withdrawn behaviors can stem from several treatable conditions, such as depression, anxiety, or other mental health disorders. Depending on a formal diagnosis, different medications may help. For mood and social withdrawal related to depression, antidepressants like selective serotonin reuptake inhibitors (SSRIs) such as sertraline or escitalopram are often prescribed. If these symptoms are associated with other psychiatric conditions, atypical antipsychotics like aripiprazole or cariprazine might be considered to help improve engagement and motivation. Because these behaviors have various causes, a comprehensive evaluation by a healthcare professional is the essential first step to safely finding the right treatment plan.