Swelling on the face along with muscle pain and shortness of breath can have several causes, such as an allergic reaction, infection, kidney problems, or fluid retention. In some cases, it may be related to conditions like Angioedema or Kidney Disease, which can cause swelling in the face and body. Because shortness of breath can be a serious symptom, it is important to seek medical evaluation. A doctor may evaluate your condition, identify the exact cause and start the appropriate treatment.