Could the self-administration of Clingen (clindamycin/clotrimazole) vaginal suppositories trigger a systemic urticarial rash in a patient with pre-existing eczema, and what are the recommended clinical steps if prescribed bepotastine fails to alleviate symptoms that worsen overnight and in the morning?
Yes, while rare, the active ingredients in Clingen (clindamycin and clotrimazole) can occasionally cause systemic allergic reactions like hives. Since your symptoms are worsening despite taking bepotastine, please temporarily stop using the Clingen suppositories. I highly recommend contacting your doctor or visiting an urgent care clinic promptly. You may need a stronger treatment, such as a short course of oral corticosteroids, to calm the reaction. Please seek immediate emergency care if you experience any swelling of your face, lips, or difficulty breathing.