Colozo 72 mcg Capsule (Linaclotide) is usually taken once daily. It should be taken on an empty stomach, about 30 minutes before your first meal of the day. Swallow the capsule whole with a full glass of water, and do not crush or chew it. Always follow your doctor’s instructions for safe and effective use. If you miss a dose, take it as soon as you remember, unless it is close to your next dose.