Calcium tablets are generally safe and do not directly worsen gallstone symptoms. However, in some people, high doses of calcium supplements may cause mild digestive discomfort, which could be mistaken for or aggravate gallbladder-related symptoms. Unilateral pedal oedema (swelling in one leg) is unlikely to be caused by liver disease, which typically affects both legs. It may instead result from heart or kidney problems, injury, infection, or certain medications. It is important to consult your doctor for proper evaluation and management.