It is highly unlikely that your symptoms point to leukemia. Your hand and leg pain could be related to your ankylosing spondylitis, as it can occasionally affect peripheral joints. Alternatively, bisoprolol (Corbis) can sometimes cause sweating or temperature changes in your hands, while sulfasalazine can occasionally cause mild aches. Sweaty palms can also simply be a normal response to stress. I recommend sharing these changes with your doctor so they can gently review your medications and ensure your arthritis is well-managed.