Limb-girdle muscular dystrophy is a group of rare inherited conditions that cause progressive weakness and wasting of the muscles around the shoulders, upper arms, thighs, and hips. It usually starts in childhood, adolescence, or early adulthood and slowly worsens over time. It is caused by genetic changes that affect proteins needed for muscle structure and function. Common symptoms include difficulty walking, climbing stairs, and lifting objects, with gradually worsening muscle weakness. There is no cure, but physiotherapy and supportive care can help manage symptoms and maintain mobility.