The persistent tiredness (fatigue) you are experiencing may be a side effect of your medications. CTD-M 6.25/25 Tablet contains Metoprolol, a beta-blocker that can cause fatigue by slowing the heart rate, and Chlorthalidone, a diuretic that may lead to low electrolyte levels (such as potassium or sodium), which can also contribute to weakness and fatigue. It is important to consult your doctor to evaluate these effects and rule out other possible causes, such as anemia, thyroid problems, or depression. Your doctor may adjust your treatment if necessary.