The main difference between these two treatments lies in their ingredients and their targets. The first medication contains only sodium fluoride and is specifically prescribed to help stabilize abnormal bone growth in the inner ear, which helps manage certain types of hearing loss. The second medication combines sodium fluoride with vitamin D3, which is typically used to support overall bone mineralization, calcium absorption, and dental health. Both are safe when used as directed, and your doctor will prescribe the specific one that matches your precise health needs.