The safety of continuing a collagen supplement with isotretinoin (Deriva I 16 mg) mainly depends on the supplement’s ingredients and your individual health condition. The key concern is avoiding any added vitamin A or related compounds, as isotretinoin is a vitamin A derivative and excess intake may increase side effects. Collagen itself is generally not a problem, but the full formulation should be reviewed carefully. Because of these factors, it is best to consult your doctor, who can review your medical reports and liver function tests and confirm whether it is safe for you to continue the supplement or recommend any changes.