Yes, a successful pregnancy is absolutely possible. The chromosomal variation (46XX, 14ps+) is generally a normal genetic variant and rarely causes miscarriages, though a genetic counselor can provide tailored reassurance. Having four miscarriages is heartbreaking, and we must find the root cause, which may involve screening for clotting or hormonal issues. While she is taking Miliana and Deviry (medroxyprogesterone) for her ovarian cyst, she should not try to conceive, as these medications prevent pregnancy and manage the cyst. Once the cyst resolves and she stops these medications, a fertility specialist can guide your next steps toward a safe, healthy pregnancy. You are not alone in this journey.