Bleeding typically starts 3 to 10 days after you finish taking your last dose of Deviry (medroxyprogesterone acetate), rather than during the course. Please give your body a few more days to respond. Your irregular periods and the 10-kilogram weight gain could indeed be linked. Hormonal imbalances, such as Polycystic Ovary Syndrome (PCOS) or thyroid issues, often cause both weight changes and irregular cycles. I highly recommend speaking with your doctor for a hormonal evaluation to help get you some answers and peace of mind.

Since the initial trial didn't induce menstruation, the next step is typically to check your hormone levels (like estrogen, thyroid, and prolactin) and perform an ultrasound to check your uterine lining. Your doctor may then suggest a combined estrogen and progesterone cycle to help prime your lining and encourage a bleed, or further investigate underlying conditions like PCOS. Please schedule a follow-up with your gynecologist.

After finishing a 5-day course of Deviry (medroxyprogesterone acetate), it is very common to experience some light spotting first. Typically, your actual withdrawal bleed or period should start anywhere from 3 to 7 days after taking your last tablet, though it can sometimes take up to 10 to 14 days. This spotting is often just a sign that your body is responding to the medication. Please try to give it a few more days. If you do not experience a normal flow after two weeks, it is a good idea to gently check in with your doctor.

The bleeding you experienced after taking Deviry (medroxyprogesterone acetate) is a withdrawal bleed, which, along with your negative blood pregnancy test, is a very strong sign that you are not pregnant. Blood pregnancy tests are highly accurate. Emergency contraceptive pills like the i-pill and hormonal treatments like Deviry can temporarily disrupt your natural cycle, leading to irregular or missed periods this month. While pregnancy is highly unlikely, taking a simple home urine pregnancy test can help ease your mind. Please consult your gynecologist to help regulate your cycle.

Prolonged or irregular bleeding despite taking medroxyprogesterone can occur due to hormonal imbalance, uterine causes like fibroids or polyps, thyroid issues, or other underlying gynaecological conditions. Since your bleeding has continued for 15 days with only partial relief, it is important to consult your gynaecologist again for reassessment. You may need further evaluation, such as an ultrasound or blood tests, to find the exact cause and adjust treatment accordingly. Do not stop or change the medicine on your own. Seek medical care promptly, especially if bleeding increases, you feel weak, dizzy, or develop other symptoms.

Since your thyroid is normal, it is safest to wait another week and repeat the home pregnancy test using your first morning urine, as ovulation might have occurred later than usual. You should avoid taking Deviry (medroxyprogesterone acetate) until you have confirmed with your healthcare provider that you are definitely not pregnant. Medroxyprogesterone acetate is used to induce a period, but ruling out pregnancy first is essential.