When starting a combined hormonal pill like Diane 35 (cyproterone acetate/ethinylestradiol), breakthrough bleeding is very common during the first few weeks as your body adjusts. Additionally, because you have an underactive thyroid and PCOS, both conditions must be fully managed together to stabilize your uterine lining. Progesterone treatments like Deviry (medroxyprogesterone) often only provide temporary relief if thyroid levels are still unbalanced. Please do not stop your medication. I highly recommend consulting your gynecologist or endocrinologist to check your thyroid levels and safely tailor your treatment.

A missed period for 40 days with a negative pregnancy test is often due to a hormonal imbalance, which can be triggered by stress, weight changes, excessive exercise, or conditions like Polycystic Ovary Syndrome or thyroid problems. In many cases, it is not serious, but it should be evaluated if it happens repeatedly. Treatment depends on the cause. Your doctor may advise lifestyle changes (healthy diet, regular exercise, stress management), check hormone levels, and sometimes prescribe medicines like progesterone (e.g., Deviry) to help induce a period. It is also a good idea to repeat the pregnancy test if there was any recent risk, or get a blood test for confirmation. If your cycles continue to be irregular or absent, a proper medical evaluation is important to ensure the right treatment and prevent long-term issues.

It is quite common for your period to be late after taking Deviry (medroxyprogesterone acetate). This medication is a hormone that can temporarily alter your cycle and delay ovulation, which often shifts your next period. Your body is simply adjusting to the hormone, and things should settle back to normal soon. To be safe and put your mind at ease, you might want to take a home pregnancy test if you have been sexually active. If your period is delayed by more than two weeks, please check in with your doctor for a quick evaluation.

Since your period is ten days late, the first step is to take a home pregnancy test if there is any chance of pregnancy. While Deviry (medroxyprogesterone) can induce a period, using it repeatedly without finding the root cause is not recommended. Recurring late periods can stem from hormonal imbalances, stress, or conditions like PCOS. Please consult your gynecologist before taking any medication. They can safely evaluate your hormone levels and help regulate your cycle naturally and safely. You are not alone, and this is very manageable with the right guidance.

Yes, there is still a risk of pregnancy, especially since her cycle is currently irregular. Before starting Femilon (desogestrel/ethinylestradiol), your wife should take a pregnancy test 14 to 21 days after taking the i-pill (levonorgestrel) to ensure she isn't pregnant. Once pregnancy is ruled out, she can safely start Femilon, ideally on the first day of her next period. Please use barrier methods like condoms if you have sex before she starts the pills, and for the first seven days of taking Femilon, to stay fully protected.

While pregnancy is a possibility and should be ruled out first with a simple home pregnancy test, there are other common reasons for not bleeding. With PCOS, your estrogen levels might be too low to build up the uterine lining, meaning there isn't enough to shed even after taking Deviry (medroxyprogesterone acetate). Please take a pregnancy test to be sure. If it is negative, I recommend reaching out to your doctor, who can help evaluate your hormone levels and guide your next steps.