Using Dexona (dexamethasone) and Avil (pheniramine) for a long period like 5 years is not considered safe without close medical supervision, especially because Dexona is a steroid that can cause serious side effects over time such as weight gain, diabetes, high blood pressure, weak bones (osteoporosis), increased infection risk, and hormonal imbalance; Avil, being an antihistamine, may cause drowsiness, dry mouth, and reduced alertness with long-term use. While these medicines do not directly damage the kidneys in most cases, long-term steroid use can indirectly affect overall health and may worsen existing conditions. It is very important not to stop Dexona suddenly, as this can cause withdrawal problems; instead, you should consult a doctor to gradually reduce and stop it safely and to find a better long-term treatment for your underlying condition.