Glycomet SR 500 (metformin) and Diapride 2 mg (glimepiride) are both used to treat type 2 diabetes, but they work in different ways: metformin mainly reduces sugar production in the liver and improves the body's response to insulin, while glimepiride increases insulin release from the pancreas. Because of this, metformin is usually the first-line medicine and has a lower risk of causing low blood sugar, whereas glimepiride can sometimes cause hypoglycemia (low sugar) if meals are skipped. Common side effects of metformin include stomach upset, gas, or loose motions (usually improving over time), while glimepiride may cause low sugar symptoms (sweating, dizziness), weight gain, or weakness. Both medicines are effective, but are chosen based on individual needs, so it is important to take only the medicine prescribed to you and not switch without consulting your doctor.