You should not stop medications like Duloxetine and Clonazepam suddenly, as this can cause withdrawal symptoms (such as anxiety, dizziness, sleep problems, or mood worsening) and relapse of depression. The safest approach is to consult your doctor, who can gradually reduce (taper) the doses over weeks to months, depending on how long you have been taking them and how stable your symptoms are. Clonazepam especially needs slow tapering to avoid dependence-related effects. Alongside this, non-medication approaches like counselling (such as cognitive behavioural therapy), regular exercise, good sleep, and stress management can help you stay well after reducing medicines. If you notice any return of depressive symptoms during tapering, inform your doctor promptly. With proper supervision, many people can safely reduce or stop medication when appropriate.

Certain medicines for depression and anxiety tend to have fewer digestive side effects, like flatulence or constipation. The best choice depends on your symptoms and medical history, so it is important to discuss this with your doctor. They can recommend an option that works well for you with minimal side effects.