The safest substitute for perphenazine, a prescription medication used for severe nausea and some mental health issues, depends on your age, dose, and other medications. Therefore, it is not recommended to replace perphenazine on your own. Other antipsychotic medications can occasionally be substituted by doctors, but this must be done carefully to prevent adverse effects or worsening symptoms. Instead of stopping it abruptly, please get in touch with your doctor, psychiatrist, or pharmacist to find the appropriate equivalent in your area.