It is generally safe to use topical sertaconazole (the antifungal ointment) while taking oral prochlorperazine (the tablet). Because the ointment is applied directly to the skin, only a negligible amount enters your bloodstream. As a result, there is no known or expected drug interaction between these two medications. You can safely continue using both as directed by your doctor. If you notice any unusual skin irritation or experience unexpected side effects, please consult your healthcare provider.