It can be challenging when a loved one refuses important medicines, especially when both heart disease and depression are involved. Medicines like Lonazep and Etilaam can help with anxiety and sleep, but they do not treat the underlying heart condition, so continuing her heart medicines is very important for her safety. Sometimes, the feeling of restlessness after taking heart medicines may be due to side effects, anxiety, or fear, so the first step is to calmly talk to her and understand exactly what she feels and when it happens. It would be helpful to discuss these symptoms with her doctor, as they may adjust the dose, change the medicine, or suggest taking it at a different time to reduce discomfort. At the same time, proper treatment of depression through counselling or appropriate antidepressant medicines can improve her overall mood and willingness to follow treatment. Family support plays a big role; gentle encouragement, involving her in decisions, and explaining the importance of heart medicines in simple terms can help build trust. Avoid forcing her, but stay consistent and supportive, and consider a joint consultation where she can openly share her concerns with the doctor. With the right adjustments and emotional support, many patients become more comfortable and regular with their treatment.