Managing thick mucus in cystic fibrosis involves a combination of daily therapies to help you breathe easier. First, inhaled medications like hypertonic saline and dornase alfa work directly to thin and loosen sticky mucus. Bronchodilators, such as albuterol, are often inhaled first to open your airways. Next, airway clearance techniques, such as chest physiotherapy or using a vibrating vest, physically help move the mucus out of your lungs. Finally, advanced prescription medications called CFTR modulators target the underlying cause of cystic fibrosis to significantly reduce overall mucus buildup. Your medical team will help design the safest, most effective daily routine for you.