To help lower your triglyceride levels, several highly effective prescription medications are available. The main options include fibrates (such as fenofibrate), which directly reduce triglyceride production in the liver, and prescription-strength omega-3 fatty acids. Statins (such as atorvastatin or rosuvastatin) are also frequently prescribed, especially if you need to manage your overall cholesterol and heart health. These medications work best when combined with simple lifestyle changes, like reducing sugar intake and staying active. Please consult your doctor to discuss which option is safest and most suitable for your specific health needs.