The most effective way to relieve itching caused by a fungal infection is to eliminate the fungus using an appropriate antifungal medication, such as Fluconazole or Terbinafine, either taken orally or applied topically for the prescribed duration. While this treats the root cause, a topical low-dose corticosteroid or oral antihistamines may be used temporarily to reduce itching, especially at night. It is important to keep the affected area clean and dry, avoid scratching, and continue the antifungal treatment even after the itching subsides to prevent reinfection.