Porokeratosis of Mibelli is a benign skin condition that can be managed effectively with prescription topical creams. Common treatments include topical fluorouracil, which targets abnormal skin cells, and imiquimod, which stimulates your local immune response to clear the lesions. Topical retinoids (such as tretinoin) or vitamin D analogues (such as calcipotriol) may also be prescribed to help normalise skin cell growth. These medications can cause mild, temporary redness or peeling as they work. Since treatment is highly personalised, please consult a dermatologist to find the best option for you and to keep these spots safely monitored.