Numbness in your leg can occur for several common reasons, such as a temporary pinched nerve in your back, poor circulation, or a mild vitamin deficiency. Because the right treatment depends entirely on the underlying cause, I do not recommend starting any specific prescription medication without a proper evaluation. For general nerve health, a vitamin B-complex supplement may be helpful, and over-the-counter options like ibuprofen can ease any accompanying discomfort. Please consult a doctor for a simple physical exam to find the exact cause. Seek immediate medical care only if you experience sudden leg weakness, difficulty walking, or loss of bowel or bladder control.