Yes, it is possible. Glyciphage G2 contains metformin and glimepiride, and the glimepiride component can sometimes trigger allergic skin reactions. Additionally, your blood sugar level of 330 mg/dL is quite high and requires prompt medical attention. Please consult your doctor or visit an urgent care clinic right away. They can safely evaluate your skin, check your blood sugar, and adjust your treatment. Please do not stop your medication without medical guidance. Taking action now will help get your blood sugar safely managed and your skin feeling better soon.