Both of these are excellent medications that work in different, complementary ways to control your blood sugar. Glynase (which contains glipizide) gently prompts your pancreas to release more insulin to lower your blood sugar. Glyciphage (which contains metformin) helps your body use its natural insulin more effectively and reduces the amount of sugar your liver produces. Together, they provide a very balanced approach to keeping your levels stable and protecting your long-term health.