Glimepiride is an oral medication used to help manage blood sugar levels in adults with type 2 diabetes, alongside a healthy diet and exercise. It belongs to a group of medicines called sulfonylureas. It works by stimulating your pancreas to release more insulin, which is the natural hormone that helps your body process and lower the sugar in your bloodstream. By helping your body produce more insulin when needed, it keeps your blood sugar within a safe, healthy range. To get the best results and prevent low blood sugar, it is usually taken with breakfast or your first main meal of the day.