Your brother's symptoms of excessive suspicion, feeling that others are talking about him, and becoming agitated suggest a chronic psychiatric condition (such as a psychotic disorder) that requires long-term, regular treatment, and the fact that his symptoms worsen when he skips medicines means the treatment is helping and should not be stopped abruptly. The best long-term management is continuous follow-up with a psychiatrist, who may adjust medicines to the lowest effective dose, switch to safer options if needed, or consider long-acting injectable medications to improve compliance. Along with medicines, psychological support, counselling, a stable routine, stress reduction, and strong family support are very important. Avoid stopping or changing medicines on your own, as this can lead to relapse or worsening symptoms. With proper and consistent treatment, many people are able to lead stable and functional lives.