Being HLA-B27 + and experiencing pain in several joints and the spine could be a sign of an inflammatory disease such ankylosing spondylitis or associated arthritis. Anti-inflammatory medications, physiotherapy, stretching exercises, posture correction, and regular exercise to maintain the flexibility of the spine are all possible treatments, depending on the severity of the symptoms. A rheumatologist must properly manage these problems, therefore avoid self-medicating for extended periods of time. Stiffness and soreness may also be lessened by using warm compresses, getting enough sleep, and quitting smoking. Seek immediate medical attention if the pain is severe, accompanied by fever, red eyes, or trouble walking.