Chest pain accompanied by discomfort in the left hand can sometimes indicate a heart-related issue, such as angina or a heart attack, particularly if accompanied by symptoms like sweating, shortness of breath, nausea, or dizziness. However, not all chest pain is cardiac in origin. Other possible causes include muscle strain, nerve compression, inflammation of the chest wall, or anxiety. Given the potential seriousness of chest pain, seeking prompt medical care is the safest course of action.