It sounds frustrating to have persistent anal irritation despite using Fluconazole. Since Fluconazole targets fungal infections but your symptoms haven't fully cleared, a combination treatment addressing both fungal infection and inflammation might help.

Onabet B Cream, which contains an antifungal (Sertaconazole nitrate) and a corticosteroid (Beclomethasone dipropionate), could reduce both fungal growth and inflammation or itching. However, this cream should be used under a doctor's supervision, especially because corticosteroids can have side effects if misused.

Next steps you can consider:

• Consult a dermatologist to confirm the diagnosis and discuss using combination creams like Onabet B Cream.
• Avoid scratching or irritating the area further; keep the area clean and dry.
• Follow the prescribed treatment duration strictly and report any worsening or side effects.
• If symptoms persist despite treatment, your doctor may investigate other causes such as bacterial infection, hemorrhoids, or skin conditions.

If you want, I can explain how to apply topical treatments safely or discuss other possible causes of anal pruritus. Please see a dermatologist for personalized care.To narrow down potential causes, we will need some more information.Please tell me your age and gender.